A. Theofilopoulos – Signal Transduction Pathways in Autoimmunity v.5

An immensely complex network of interactions between multiple cell types and cytokines regulates the immune system. Ligand binding to antigen-specific, Fc, or cytokine receptors initiates differentiation, activation and proliferation of multiple immune system cell lineages. These activating pathways are counteracted by inhibitory receptors. In the past two decades, considerable work on mechanistic and functional details of such intracellular signaling pathways has led to the realization that an