M. Caruthers – Oligonucleotides as Therapeutic Agents

This wide-ranging book includes discussion of Chemistry of Death ebook pdf mobi epub" style="text-decoration: underline">the chemistry of oligonucleotide analogues, and reports on studies of the pharmacokinetics of oligonucleotides conducted in cell cultures and in vivo. Surveying the results of structure-activity studies and current clinical trials, it concludes with reviews of applications of ribozymes, aptamers (oligonucleotides which bind specifically to proteins), and discussion of triplex-forming oligonucleotides.